CUL4B regulates thyroid cancer differentiation and treatment sensitivity by ubiquitinating ARID1A

CUL4B regulates thyroid cancer differentiation and treatment sensitivity by ubiquitinating ARID1A

Background: Thyroid cancer (TC) is a prevalent endocrine malignancy with a generally favorable prognosis. However, dedifferentiation of TC poses a significant challenge, resulting in poorer patient outcomes and necessitating urgent attention. Cullin 4B (CUL4B), a scaffold protein involved in proteol...

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Bibliographic Details
Main Authors: Haiyan Gu, Bo Han, Jing Hu, Ping Liu, Wenyao Liu, Ying Qu, Lin Zhang, Panpan Li, Gongzheng Wang, Zhiyan Liu, Mei Qi, Feifei Sun
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Translational Oncology
Subjects:
CUL4B
Thyroid cancer
Differentiation
ARID1A
MAPK
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523325001202
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