The Antitumor Role of Incomptine A in a Breast Cancer Murine Model: Impairment of Hexokinase II Expression and Apoptosis Induction

The Antitumor Role of Incomptine A in a Breast Cancer Murine Model: Impairment of Hexokinase II Expression and Apoptosis Induction

Breast cancer (BC) is the most common type of cancer in women worldwide. Hexokinase II (HKII) overexpression is associated with the proliferation and survival of tumor cells, as it inhibits apoptosis. Incomptine A (IA) is cytotoxic to breast cancer cells, likely due to a decrease in the expression o...

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Bibliographic Details
Main Authors: Angel Giovanni Arietta-García, Fernando Calzada, Antonio Franco-Vadillo, Irais Monserrat Barrientos-Buendía, Francisco Javier Alarcón-Aguilar, Elihú Bautista, Paola Santana-Sánchez, Israel Ramírez-Sánchez, Rosa María Ordoñez-Razo
Format: Article
Language:English
Published: MDPI AG 2025-08-01
Series:Cells
Subjects:
incomptine A
antitumor activity
breast cancer
hexokinase II
apoptosis
Online Access:https://www.mdpi.com/2073-4409/14/15/1192
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https://www.mdpi.com/2073-4409/14/15/1192

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