Whole‑exome evolutionary profiling of osteosarcoma uncovers metastasis‑related driver mutations and generates an independently validated predictive classifier

Whole‑exome evolutionary profiling of osteosarcoma uncovers metastasis‑related driver mutations and generates an independently validated predictive classifier

Abstract Background Osteosarcoma is the most common primary malignant bone tumor, with high invasiveness and metastatic potential and a poor prognosis in patients with metastatic cancer. Despite the rapid advancements in genomics in recent years that provided new perspectives for studying the molecu...

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Bibliographic Details
Main Authors: Zhen Wang, Zhe Wang, Ruoyu Wang, Zumin Wang, Xiangyang Cao, Rui Chen, Zebing Ma, Shanshan Liang, Shuai Tao
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Osteosarcoma
Metastasis
Tumor evolution
Machine learning
Cohort analysis
Online Access:https://doi.org/10.1186/s12967-025-06796-6
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https://doi.org/10.1186/s12967-025-06796-6

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