miR-6516-3p-mediated downregulation of the endogenous MMP-9 inhibitor RECK in mesangial cells might exacerbate lupus nephritis

miR-6516-3p-mediated downregulation of the endogenous MMP-9 inhibitor RECK in mesangial cells might exacerbate lupus nephritis

Abstract Background MicroRNAs (miRNAs) regulate biological processes by inhibiting translation and causing mRNA degradation. In this study, we identified the miRNAs involved in the development and progression of lupus nephritis (LNs) and verified their roles. Methods Total RNA, extracted from PBMCs...

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Main Authors: Hiroyuki Tomita, Kunihiro Hayakawa, Keigo Ikeda, Hiroshi Tsushima, Marina Shinoura, Maki Fujishiro, Yuko Kataoka, Ken Yamaji, Kenji Takamori, Naoto Tamura, Iwao Sekigawa, Shinji Morimoto
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Molecular Medicine
Subjects:
microRNA (miRNA)
miR-6516-3p
Lupus nephritis
Systemic lupus erythematosus (SLE)
Normal human glomerular mesangial cells (NHMC)
RECK
Online Access:https://doi.org/10.1186/s10020-025-01124-6
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https://doi.org/10.1186/s10020-025-01124-6

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