5′ DREDGE: Direct Repeat-Enabled Downregulation of Gene Expression via the 5′ UTR of Target Genes

5′ DREDGE: Direct Repeat-Enabled Downregulation of Gene Expression via the 5′ UTR of Target Genes

Despite the availability of numerous methods for controlling gene expression, there remains a strong need for technologies that maximize two key properties: selectivity and reversibility. To this end, we developed a novel approach that exploits the highly sequence-specific nature of CRISPR-associate...

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Bibliographic Details
Main Authors: Sagar J. Parikh, Heather M. Terron, Luke A. Burgard, Dylan D. Butler, Frank M. LaFerla, Shelley Lane, Malcolm A. Leissring
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Cells
Subjects:
CRISPR
direct repeat
DREDGE
endoribonuclease
gene regulation
Online Access:https://www.mdpi.com/2073-4409/14/12/866
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https://www.mdpi.com/2073-4409/14/12/866

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