Structures of G-protein coupled receptor HCAR1 in complex with Gi1 protein reveal the mechanistic basis for ligand recognition and agonist selectivity.

Structures of G-protein coupled receptor HCAR1 in complex with Gi1 protein reveal the mechanistic basis for ligand recognition and agonist selectivity.

Hydroxycarboxylic acid receptor 1 (HCAR1), also known as lactate receptor or GPR81, is a class A G-protein-coupled receptor with key roles in regulating lipid metabolism, neuroprotection, angiogenesis, cardiovascular function, and inflammatory response in humans. HCAR1 is highly expressed in numerou...

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Main Authors: Xin Pan, Fang Ye, Peiruo Ning, Yiping Yu, Zhiyi Zhang, Jingxuan Wang, Geng Chen, Zhangsong Wu, Chen Qiu, Jiancheng Li, Bangning Chen, Lizhe Zhu, Chungen Qian, Kaizheng Gong, Yang Du
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-04-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3003126
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https://doi.org/10.1371/journal.pbio.3003126

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