Regulatory T cells require peripheral CCL2-CCR2 signaling to facilitate the resolution of medication overuse headache-related behavioral sensitization

Regulatory T cells require peripheral CCL2-CCR2 signaling to facilitate the resolution of medication overuse headache-related behavioral sensitization

Abstract Background Medication overuse headache (MOH) is the most common secondary headache disorder, resulting from chronic and excessive use of medication to treat headaches, for example, sumatriptan. In a recent study, we have shown that the peripheral C-C motif ligand 2 (CCL2), C-C motif chemoki...

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Bibliographic Details
Main Authors: Sun Ryu, Jintao Zhang, Roli Simoes, Xuemei Liu, Zhaohua Guo, Li Feng, Jacqueline Unsinger, Richard S. Hotchkiss, Yu-Qing Cao
Format: Article
Language:English
Published: BMC 2024-11-01
Series:The Journal of Headache and Pain
Subjects:
Medication overuse headache
Facial mechanical hypersensitivity
C-C motif ligand 2 (CCL2)
C-C motif chemokine receptor 2 (CCR2)
Calcitonin gene-related peptide (CGRP)
Regulatory T (Treg) cell
Online Access:https://doi.org/10.1186/s10194-024-01900-5
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https://doi.org/10.1186/s10194-024-01900-5

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