Proof-of-concept MALDI-TOF-MS assay for the detection of Toxin B enzymatic activity in Clostridioides difficile infection

Proof-of-concept MALDI-TOF-MS assay for the detection of Toxin B enzymatic activity in Clostridioides difficile infection

ABSTRACT Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometers have become an integral part of all modern clinical microbiology laboratories. They serve as the key tool for pathogen identification and antibiotic resistance determination. However, certain limiting...

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Main Authors: Josef Dvorak, Lukáš Fojtík, Ljubina Adámková, Katerina Vlkova, Vendula Studentova, Katerina Chudejova, Lenka Geigerová, Michael Volny, Petr Novak, Jaroslav Hrabak, Petr Pompach
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:Microbiology Spectrum
Subjects:
C. difficile
Toxin B
MALDI-TOF-MS
diagnostics
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02453-24
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https://journals.asm.org/doi/10.1128/spectrum.02453-24

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