Characterization of in vivo binding kinetics and non-displaceable binding of [18F]SynvesT-1 in the rat brain

Characterization of in vivo binding kinetics and non-displaceable binding of [18F]SynvesT-1 in the rat brain

Abstract Background The synaptic vesicle glycoprotein 2 A (SV2A) has been identified as a biomarker of interest for neurological pathology. The SV2A specific radiotracer [18F]SynVesT-1 has shown good binding characteristics in mouse and human. The aim of this study was to characterize the binding pa...

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Main Authors: Catriona Wimberley, Carlos J. Alcaide-Corral, Timaeus E. F. Morgan, Mark G. Macaskill, Bernadette Andrews, Holly McErlain, Valeria K. Burianova, Andrew Sutherland, Adriana A. S. Tavares
Format: Article
Language:English
Published: SpringerOpen 2025-06-01
Series:EJNMMI Research
Subjects:
Rat
[18F]SynVesT-1
SV2A
Mass dose
Preclinical PET
Online Access:https://doi.org/10.1186/s13550-025-01270-2
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https://doi.org/10.1186/s13550-025-01270-2

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