Disentangling the divergent causal pathways underlying the association between body mass index and bone mineral density: a comprehensive Mendelian randomization study

Disentangling the divergent causal pathways underlying the association between body mass index and bone mineral density: a comprehensive Mendelian randomization study

Abstract Background While the protective role of body mass index (BMI) in bone mass has been well-documented, the divergent associations between BMI and estimated bone mineral density (eBMD), attributed to its highly heterogeneous nature, remain insufficiently understood. Methods Leveraging the hith...

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Main Authors: Xunying Zhao, Lin He, Xueyao Wu, Li Zhang, Jinyu Xiao, Changfeng Xiao, Yang Qu, Jingwei Zhu, Chenjiarui Qin, Deqin Huang, Pengyue Shen, Tao Han, Mengyu Fan, Jiayuan Li, Stephen Burgess, Xia Jiang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Medicine
Subjects:
Body mass index
Estimated bone mineral density
Mendelian randomization
Divergent causal pathways
Causal inference
Online Access:https://doi.org/10.1186/s12916-025-04139-2
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https://doi.org/10.1186/s12916-025-04139-2

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