Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment

Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment

This review explores the recent advancements in polymer-assisted delivery systems for antisense oligonucleotides (ASOs) and their potential in precision disease treatment. Synthetic polymers have shown significant promise in enhancing the delivery, stability, and therapeutic efficacy of ASOs by addr...

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Bibliographic Details
Main Authors: Ana Cubillo Alvarez, Dylan Maguire, Ruairí P. Brannigan
Format: Article
Language:English
Published: Beilstein-Institut 2025-03-01
Series:Beilstein Journal of Nanotechnology
Subjects:
antisense oligonucleotides
enhanced delivery
gene transfection
intracellular uptake
locked nucleic acid (lna)
nanoparticles
peptide nucleic acid (pna)
personalised therapy
phosphorodiamidate morpholino oligomer (pmo)
phosphorothioate (ps)
polyplexes
ribose substitutions
small interfering rna (sirna)
synthetic polymers
tricyclo-dna (tcdna)
Online Access:https://doi.org/10.3762/bjnano.16.34
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https://doi.org/10.3762/bjnano.16.34

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