Sequence-based prioritization of i-Motif candidates in the human genome

Introductioni-Motifs (iMs) are cytosine-rich, four-stranded DNA structures with emerging roles in gene regulation and genome stability. Despite their biological relevance, genome-wide prediction of iM-forming sequences remains limited by low specificity and high false-positive rates, leading to cons...

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Bibliographic Details
Main Authors: Veronica Remori, Michela Prest, Mauro Fasano
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Bioinformatics
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Online Access:https://www.frontiersin.org/articles/10.3389/fbinf.2025.1657841/full
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