Comparative efficacy of remifentanil and fentanyl in mechanically ventilated ICU patients: a systematic review and meta-analysis on ventilation duration and delirium incidence

Comparative efficacy of remifentanil and fentanyl in mechanically ventilated ICU patients: a systematic review and meta-analysis on ventilation duration and delirium incidence

Abstract Background The ultrashort-acting properties and organ-independent metabolism of remifentanil may be advantageous in mechanical ventilation management. Unlike fentanyl, which accumulates over time and may prolong sedation, remifentanil enables more predictable titration and rapid weaning. Th...

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Main Authors: Hiromu Okano, Eriya Imai, Hiroshi Okamoto, Masaaki Sakuraya, Yoshitaka Aoki, Shun Muramatsu, Misa Kitamura, Tsutomu Yamazaki, Yuki Kataoka
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Anesthesia, Analgesia and Critical Care
Subjects:
Remifentanil
Fentanyl
Mechanical ventilation
Meta-analysis
Systematic review
Critical care
Online Access:https://doi.org/10.1186/s44158-025-00258-7
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https://doi.org/10.1186/s44158-025-00258-7

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