PARylation of HMGA1 desensitizes esophageal squamous cell carcinoma to olaparib

PARylation of HMGA1 desensitizes esophageal squamous cell carcinoma to olaparib

Abstract As a chromatin remodelling factor, high mobility group A1 (HMGA1) plays various roles in both physiological and pathological conditions. However, its role in DNA damage response and DNA damage‐based chemotherapy remains largely unexplored. In this study, we report the poly ADP‐ribosylation...

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Main Authors: Xin‐Yuan Lei, Kai‐Yue He, Qiu‐Tong Li, Lei Zhang, Dan‐Hui Wu, Jing‐Yu Yang, Jin‐Rong Guo, Meng‐Jie Liu, Zi‐Long Zhao, Jun‐Qi Li, Huai Liu, Yuan Zhao, Yu‐Jia Li, Qian‐Hui Sun, Chen‐Guang Wu, Yun‐Fan Wang, Geng‐Sheng Cao, Gang Wang, Yong‐Ping Jian, Zhi‐Xiang Xu
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Clinical and Translational Medicine
Subjects:
chemotherapy sensitivity
DNA damage
ESCC
HMGA1
Olaparib
PARP1
Online Access:https://doi.org/10.1002/ctm2.70111
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https://doi.org/10.1002/ctm2.70111

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