BASE: a web service for providing compound-protein binding affinity prediction datasets with reduced similarity bias

BASE: a web service for providing compound-protein binding affinity prediction datasets with reduced similarity bias

Abstract Background Deep learning-based drug-target affinity (DTA) prediction methods have shown impressive performance, despite a high number of training parameters relative to the available data. Previous studies have highlighted the presence of dataset bias by suggesting that models trained solel...

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Bibliographic Details
Main Authors: Hyojin Son, Sechan Lee, Jaeuk Kim, Haangik Park, Myeong-Ha Hwang, Gwan-Su Yi
Format: Article
Language:English
Published: BMC 2024-10-01
Series:BMC Bioinformatics
Subjects:
Drug-target affinity prediction
Drug discovery
Deep learning
Dataset bias
Protein similarity
Online Access:https://doi.org/10.1186/s12859-024-05968-3
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https://doi.org/10.1186/s12859-024-05968-3

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