A hybrid epithelial-mesenchymal transition program enables basal epithelial cells to bypass stress-induced stasis and contributes to a metaplastic breast cancer progenitor state

A hybrid epithelial-mesenchymal transition program enables basal epithelial cells to bypass stress-induced stasis and contributes to a metaplastic breast cancer progenitor state

Abstract Background Human mammary epithelial cell (HMEC) cultures encounter a stress-associated barrier termed stasis, during which most cells adopt a senescence-like phenotype. From these cultures, rare variants emerge from the basal epithelial population, re-initiating growth. Variants exhibit pre...

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Bibliographic Details
Main Authors: Joseph A. Caruso, Chira Chen-Tanyolac, Thea D. Tlsty
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Breast Cancer Research
Subjects:
Human mammary epithelial cells
Basal
Myoepithelial
TGF-β pathway
Epithelial-mesenchymal transition
Epigenetic regulation
Online Access:https://doi.org/10.1186/s13058-024-01920-8
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https://doi.org/10.1186/s13058-024-01920-8

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