The Chemokine (C-C Motif) Receptor 1 Antagonist BX471 Improves Fluid Resuscitation in Rat Models of Hemorrhagic Shock

The Chemokine (C-C Motif) Receptor 1 Antagonist BX471 Improves Fluid Resuscitation in Rat Models of Hemorrhagic Shock

<b>Background/Objectives</b>: We reported previously that antagonists at chemokine receptors CCR2 and CCR3 have fluid-sparing effects during resuscitation from hemorrhagic shock. Because CCR1 shares several chemokine ligands with CCR2/3, we tested whether the CCR1 antagonist BX471 also r...

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Bibliographic Details
Main Authors: Elizabeth A. Cook, Ololade Ogunsina, Xianlong Gao, Matthias Majetschak
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomedicines
Subjects:
chemokine receptor antagonists
chemokine (C-C motif) receptor 1
hemorrhagic shock
fluid resuscitation strategies
Online Access:https://www.mdpi.com/2227-9059/13/5/1241
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