Proline-driven metabolic reprogramming promotes skeletal muscle hypertrophy and oxidative myofiber specification in porcine offspring: a stage-optimized maternal nutritional intervention

Proline-driven metabolic reprogramming promotes skeletal muscle hypertrophy and oxidative myofiber specification in porcine offspring: a stage-optimized maternal nutritional intervention

Abstract Background While maternal proline (Pro) supplementation has demonstrated efficacy in enhancing placental angiogenesis and farrowing efficiency in swine, its regulatory role in fetal skeletal muscle ontogeny remains undefined. This study systematically evaluated the temporal-specific impacts...

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Main Authors: Jun Huang, Kaidi Ma, Junyi Wu, Shuangbo Huang, Zihao Huang, Yujiao Chen, Shijian Zhou, Hefeng Luo, Chengquan Tan
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Animal Science and Biotechnology
Subjects:
Mitochondrial function
Oxidative muscle fibers
Proline
Skeletal muscle development
STAT3 signaling pathway
Online Access:https://doi.org/10.1186/s40104-025-01232-7
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https://doi.org/10.1186/s40104-025-01232-7

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