Preclinical efficacy of multi-targeting mRNA-based CAR T cell therapy in resection models of glioblastoma

Preclinical efficacy of multi-targeting mRNA-based CAR T cell therapy in resection models of glioblastoma

Traditional viral-based chimeric antigen receptor (CAR) T cell therapies have vanquished multiple blood malignancies with decade-long remissions yet struggle against solid tumors. Nonviral engineering of CAR T cells via electroporation or lipid nanoparticle (LNP) delivery of CAR-encoding mRNA result...

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Bibliographic Details
Main Authors: Oula K. Dagher, Martin Pedard, Darel Martinez Bedoya, Shawna K. Brookens, Denis Migliorini, Avery D. Posey, Jr.
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Delivery Strategies
chimeric antigen receptor T cells
messenger RNA
glioblastoma
immunotherapy
multiple targeting
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253125002306
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