Dual α-amylase and α-glucosidase inhibition by 1,2,4-triazole derivatives for diabetes treatment

Dual α-amylase and α-glucosidase inhibition by 1,2,4-triazole derivatives for diabetes treatment

Abstract The development of effective antidiabetic agents remains a critical challenge in diabetes management. In this study, we introduce novel 1,2,4-triazole-based derivatives designed as dual inhibitors of α-amylase and α-glucosidase, key enzymes in carbohydrate metabolism. Molecular docking iden...

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Bibliographic Details
Main Authors: Mohammed A. Marzouk, Elsayed M. Mahmoud, Wesam S. Shehab, Sherif M. Fawzy, Samar M. Mohammed, Mahmoud Ashraf Abdel-Razek, Ghada E. Khedr, Doaa A. Elsayed
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
1,2,4-Triazole derivatives
Anti-diabetic activity
α-Amylase inhibitors
α-Glucosidase inhibitors
Molecular docking analysis
In vitro enzyme inhibition
Online Access:https://doi.org/10.1038/s41598-025-11214-4
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https://doi.org/10.1038/s41598-025-11214-4

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