Discovery of Specific Inhibitors for Intestinal E. coli β-Glucuronidase through In Silico Virtual Screening
Glucuronidation is a major metabolism process of detoxification for carcinogens, 4-(methylnitrosamino)-1-(3-pyridy)-1-butanone (NNK) and 1,2-dimethylhydrazine (DMH), of reactive oxygen species (ROS). However, intestinal E. coli β-glucuronidase (eβG) has been considered pivotal to colorectal carcin...
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| Main Authors: | Ta-Chun Cheng, Kuo-Hsiang Chuang, Steve R. Roffler, Kai-Wen Cheng, Yu-Lin Leu, Chih-Hung Chuang, Chien-Chaio Huang, Chien-Han Kao, Yuan-Chin Hsieh, Long-Sen Chang, Tian-Lu Cheng, Chien-Shu Chen |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2015/740815 |
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