Discovery of Specific Inhibitors for Intestinal E. coli  β-Glucuronidase through In Silico Virtual Screening

Discovery of Specific Inhibitors for Intestinal E. coli  β-Glucuronidase through In Silico Virtual Screening

Glucuronidation is a major metabolism process of detoxification for carcinogens, 4-(methylnitrosamino)-1-(3-pyridy)-1-butanone (NNK) and 1,2-dimethylhydrazine (DMH), of reactive oxygen species (ROS). However, intestinal E. coli   β-glucuronidase (eβG) has been considered pivotal to colorectal carcin...

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Main Authors: Ta-Chun Cheng, Kuo-Hsiang Chuang, Steve R. Roffler, Kai-Wen Cheng, Yu-Lin Leu, Chih-Hung Chuang, Chien-Chaio Huang, Chien-Han Kao, Yuan-Chin Hsieh, Long-Sen Chang, Tian-Lu Cheng, Chien-Shu Chen
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1155/2015/740815
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http://dx.doi.org/10.1155/2015/740815

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