FAAH Inhibition Reverses Depressive-like Behavior and Sex-Specific Neuroinflammatory Alterations Induced by Early Life Stress

FAAH Inhibition Reverses Depressive-like Behavior and Sex-Specific Neuroinflammatory Alterations Induced by Early Life Stress

Early life stress (ELS) increases predisposition to major depressive disorder (MDD), with neuroinflammation playing a crucial role. This study investigated the long-term effects of the fatty acid amide hydrolase (FAAH) inhibitor URB597 on ELS-induced depressive-like behavior and messenger RNA (mRNA)...

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Bibliographic Details
Main Authors: Anna Portugalov, Irit Akirav
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Cells
Subjects:
cannabinoids
depression
early life stress
neuroinflammation
URB597
Online Access:https://www.mdpi.com/2073-4409/13/22/1881
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https://www.mdpi.com/2073-4409/13/22/1881

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