Risk assessment of antibody-mediated damage based on the detection of HLA and non-HLA antibodies toward extracellular antigens before kidney transplantation

Risk assessment of antibody-mediated damage based on the detection of HLA and non-HLA antibodies toward extracellular antigens before kidney transplantation

IntroductionDonor-specific human leukocyte antigens antibodies (HLA-DSA) contribute toantibody-mediated rejection (ABMR) after kidney transplantation (KT). Non-HLA antibodies may play a role in ABMR in the presence of HLA-DSA or the development of microvascular inflammation (MVI) in its absence. Con...

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Main Authors: Eulàlia Solà-Porta, Dolores Redondo-Pachón, Jorge Eguía-Núñez, Anna Buxeda, José Luís Caro, Javier Gimeno, Luís Campuzano, Carla Burballa, Betty Chamoun, Sara Sanz-Ureña, Judith Federico-Vega, Elisenda Alari-Pahissa, Julio Pascual, María José Pérez-Sáez, Marta Crespo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
non-HLA antibodies
HLA
ABMR
antibody-mediated rejection
MVI
microvascular inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1614408/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1614408/full

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