Differential trypanosome surface coat regulation by a CCCH protein that co-associates with procyclin mRNA cis-elements.

The genome of Trypanosoma brucei is unusual in being regulated almost entirely at the post-transcriptional level. In terms of regulation, the best-studied genes are procyclins, which encode a family of major surface GPI-anchored glycoproteins (EP1, EP2, EP3, GPEET) that show differential expression...

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Bibliographic Details
Main Authors: Pegine Walrad, Athina Paterou, Alvaro Acosta-Serrano, Keith R Matthews
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-02-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000317&type=printable
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