Systems biology-based assessment of immune responses to whole cell and acellular pertussis vaccines

Systems biology-based assessment of immune responses to whole cell and acellular pertussis vaccines

Abstract Given the local and systemic adverse reactions associated with whole-cell pertussis vaccines combined with diphtheria and tetanus toxoids (DTP), acellular pertussis vaccines combined with the same toxoids (DTaP) were developed in the 1990s. In comparison to DTP, DTaP vaccines demonstrated r...

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Main Authors: Mariana Leguia, Antón Vila-Sanjurjo, Diana Juarez, Alejandra Garcia-Glaessner, Ana I. Gil, Mayita Alvarez, Rubelio Cornejo, Sami Cherikh, Casey E. Gelber, Johannes B. Goll, Leigh M. Howard, Natalia Jimenez-Truque, Kathryn M. Edwards, C. Buddy Creech, Claudio F. Lanata
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01121-0
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https://doi.org/10.1038/s41541-025-01121-0

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