FOLR2+ macrophage depletion from intestinal metaplasia to early gastric cancer: single-cell sequencing insight into gastric cancer progression

FOLR2+ macrophage depletion from intestinal metaplasia to early gastric cancer: single-cell sequencing insight into gastric cancer progression

Abstract Background The immune landscape associated with different subtypes of intestinal metaplasia (IM) and early gastric cancer (EGC) remains unclear. This study aimed to investigate the immune landscape of complete intestinal metaplasia (CIM), incomplete intestinal metaplasia (IIM), and EGC, as...

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Bibliographic Details
Main Authors: Yuxin He, Jiayu Wang, Zilin Deng, Huang Feng, Mingzhan Du, Deqing Zhang, Guangbo Zhang, Tongguo Shi, Weichang Chen
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Intestinal metaplasia
Early gastric cancer
Malignant transformation
Single-cell RNA sequencing
FOLR2+ macrophages
CD8+T cells
Online Access:https://doi.org/10.1186/s13046-024-03245-y
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https://doi.org/10.1186/s13046-024-03245-y

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