Acute gabapentin administration in healthy adults. A double-blind placebo-controlled study using transcranial magnetic stimulation and 7T 1H-MRS

Acute gabapentin administration in healthy adults. A double-blind placebo-controlled study using transcranial magnetic stimulation and 7T 1H-MRS

Gamma-aminobutyric acid (GABA) and glutamate are the primary neurotransmitters responsible for modulating excitatory and inhibitory signalling within the human brain. Dysfunctional GABAergic and glutamatergic signalling has been identified as a key factor in a range of neuropsychiatric conditions; h...

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Bibliographic Details
Main Authors: Katherine Dyke, Sophia E. Pépés, Ben Babourina-Brooks, Chen Chen, Soyoung Kim, Hilmar P. Sigurdsson, Amelia Draper, Masud Husain, Parashkev Nachev, Penny Gowland, Peter G. Morris, Stephen R. Jackson
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:NeuroImage: Reports
Subjects:
Gamma-aminobutyric acid (GABA)
Glutamate (Glu)
Glutamine (Gln)
Magnetic resonance spectroscopy (MRS)
Transcranial magnetic stimulation (TMS)
Short interval intracortical inhibition (SICI)
Online Access:http://www.sciencedirect.com/science/article/pii/S2666956021000015
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