SIRT5 regulates granulosa cell proliferation and apoptosis in polycystic ovarian syndrome via desuccinylation of GLI1

SIRT5 regulates granulosa cell proliferation and apoptosis in polycystic ovarian syndrome via desuccinylation of GLI1

Polycystic ovarian syndrome (PCOS) is a major cause of infertility. Succinylation is involved in disease processes; however, its role in PCOS remains unknown. This study aimed to analyze the effect of desuccinylase SIRT5 on granulosa cell phenotype and the molecular mechanism. The levels of succinyl...

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Bibliographic Details
Main Authors: Yiwen Zhang, Fangfang He, Ning Cai, Guanmei Chen, Yinyin Wang, Weiwei Bai, Peng Guo
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Gynecological Endocrinology
Subjects:
SIRT5
succinylation
GLI1
granulosa cells
SHH pathway
polycystic ovarian syndrome
Online Access:https://www.tandfonline.com/doi/10.1080/09513590.2025.2515516
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https://www.tandfonline.com/doi/10.1080/09513590.2025.2515516

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