METTL3 and METTL14 drive pancreatic adenocarcinoma progression via m6A-dependent alternative splicing in PANC-1 cells

METTL3 and METTL14 drive pancreatic adenocarcinoma progression via m6A-dependent alternative splicing in PANC-1 cells

Abstract METTL3 and METTL14, key components of the m6A methyltransferase complex, have been extensively studied in the context of various cancers. However, their roles in regulating alternative splicing in pancreatic cancer remain largely unexplored. In this study, we analyzed high-throughput RNA-se...

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Bibliographic Details
Main Authors: Bo Tang, LianMin Wang, Dong Wei, Tao Wang, Renchao Zou, Kun Su, Tao Wu, Dongyun Cun, Qiuhong Wang
Format: Article
Language:English
Published: Springer 2025-08-01
Series:Discover Oncology
Subjects:
Pancreatic cancer
METTL3_14
Alternative splicing
m6A
Online Access:https://doi.org/10.1007/s12672-025-03393-3
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https://doi.org/10.1007/s12672-025-03393-3

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