A Repurposed Drug Selection Pipeline to Identify CNS-Penetrant Drug Candidates for Glioblastoma

A Repurposed Drug Selection Pipeline to Identify CNS-Penetrant Drug Candidates for Glioblastoma

Background: Glioblastoma is an aggressive and incurable type of brain cancer. Little progress has been made in the development of effective new therapies in the past decades. The blood–brain barrier (BBB) and drug efflux pumps, which together hamper drug delivery to these tumors, play a pivotal role...

Full description

Saved in:
Bibliographic Details
Main Authors: Ioannis Ntafoulis, Stijn L. W. Koolen, Olaf van Tellingen, Chelsea W. J. den Hollander, Hendrika Sabel-Goedknegt, Stephanie Dijkhuizen, Joost Haeck, Thom G. A. Reuvers, Peter de Bruijn, Thierry P. P. van den Bosch, Vera van Dis, Zhenyu Gao, Clemens M. F. Dirven, Sieger Leenstra, Martine L. M. Lamfers
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Pharmaceuticals
Subjects:
glioblastoma
BBB
ABC transporters
CNS-MPO
pharmacokinetics
PDX models
Online Access:https://www.mdpi.com/1424-8247/17/12/1687
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/1424-8247/17/12/1687

Similar Items