The STING-activating nanofactory relieves T cell exhaustion in Mn-based tumor immunotherapy by regulating mitochondrial dysfunction

The STING-activating nanofactory relieves T cell exhaustion in Mn-based tumor immunotherapy by regulating mitochondrial dysfunction

Abstract Manganese-based STING-activating tumor immunotherapy faces limitations due to T cell exhaustion. Mitochondrial dysfunction is a key factor contributing to T cell exhaustion. Modulating mitochondrial function during manganese-based immunotherapy offers a promising strategy to reverse T cell...

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Main Authors: Nana Chen, Yushan Yang, Limin Fan, Yanni Cai, Weimin Yin, Zichen Yang, Yuge Zhao, Shiyu Chen, Hui Zhi, Liangyi Xue, Xiaoyou Zhang, Lulu An, Yongyong Li, Tianbin Ren
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Nanobiotechnology
Subjects:
Mn-based tumor immunotherapy
STING pathway
T cell exhaustion
Mitochondrial dysfunction
Liposome
Online Access:https://doi.org/10.1186/s12951-025-03469-w
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https://doi.org/10.1186/s12951-025-03469-w

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