Single‐cell analysis of population context advances RNAi screening at multiple levels

Single‐cell analysis of population context advances RNAi screening at multiple levels

Abstract Isogenic cells in culture show strong variability, which arises from dynamic adaptations to the microenvironment of individual cells. Here we study the influence of the cell population context, which determines a single cell's microenvironment, in image‐based RNAi screens. We developed...

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Main Authors: Berend Snijder, Raphael Sacher, Pauli Rämö, Prisca Liberali, Karin Mench, Nina Wolfrum, Laura Burleigh, Cameron C Scott, Monique H Verheije, Jason Mercer, Stefan Moese, Thomas Heger, Kristina Theusner, Andreas Jurgeit, David Lamparter, Giuseppe Balistreri, Mario Schelhaas, Cornelis A M De Haan, Varpu Marjomäki, Timo Hyypiä, Peter J M Rottier, Beate Sodeik, Mark Marsh, Jean Gruenberg, Ali Amara, Urs Greber, Ari Helenius, Lucas Pelkmans
Format: Article
Language:English
Published: Springer Nature 2012-04-01
Series:Molecular Systems Biology
Subjects:
cell‐to‐cell variability
image analysis
population context
RNAi
virus infection
Online Access:https://doi.org/10.1038/msb.2012.9
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https://doi.org/10.1038/msb.2012.9

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