Molecular Mechanisms and Clinical Divergences in HPV-Positive Cervical vs. Oropharyngeal Cancers: A Critical Narrative Review

Molecular Mechanisms and Clinical Divergences in HPV-Positive Cervical vs. Oropharyngeal Cancers: A Critical Narrative Review

Abstract Human papillomavirus (HPV) plays a pivotal role in the development of both cervical squamous cell carcinoma (CSCC) and oropharyngeal squamous cell carcinoma (OPSCC). However, these two cancers exhibit markedly different clinical behaviors. While HPV-positive OPSCC is distinguished by its he...

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Main Authors: Canio Martinelli, Alfredo Ercoli, Silvana Parisi, Giuseppe Iatì, Stefano Pergolizzi, Luigi Alfano, Francesca Pentimalli, Michelino De Laurentiis, Antonio Giordano, Salvatore Cortellino
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Medicine
Subjects:
Human papillomavirus
Cervical cancer
Oropharyngeal cancer
Molecular oncology
Radiosensitivity
Online Access:https://doi.org/10.1186/s12916-025-04247-z
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https://doi.org/10.1186/s12916-025-04247-z

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