A perfect islet: reviewing recent protocol developments and proposing strategies for stem cell derived functional pancreatic islets

A perfect islet: reviewing recent protocol developments and proposing strategies for stem cell derived functional pancreatic islets

Abstract The search for an effective cell replacement therapy for diabetes has driven the development of “perfect” pancreatic islets from human pluripotent stem cells (hPSCs). These hPSC-derived pancreatic islet-like β cells can overcome the limitations for disease modelling, drug development and tr...

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Main Authors: Sujitha Sali, Leen Azzam, Taraf Jaro, Ahmed Ali Gebril Ali, Ali Mardini, Omar Al-Dajani, Shahryar Khattak, Alexandra E. Butler, Juberiya M. Azeez, Manjula Nandakumar
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Stem Cell Research & Therapy
Subjects:
Pancreatic islet
Stem cells
Human induced pluripotency
Differentiation protocols
Mature Β cells
Online Access:https://doi.org/10.1186/s13287-025-04293-7
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https://doi.org/10.1186/s13287-025-04293-7

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