Themis differentially regulates T follicular helper cell differentiation during early and late stages of chronic viral infection

Themis differentially regulates T follicular helper cell differentiation during early and late stages of chronic viral infection

IntroductionT follicular helper (TFH) cells are critical for humoral immunity during chronic viral infection, but the mechanisms guiding their differentiation from a novel CD4⁺ T cell progenitors remain incompletely understood. Themis, a T cell-specific adaptor protein, has been implicated in T cell...

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Main Authors: Yuzhen Zhu, Yuzhou Bao, Ning Wang, Qifeng Gan, Jian Tang, Yu Cong, Bowen Hou, Minxue Quan, Chaonan Yan, Siyi Liu, Shuo Lin, Xiaobin Zhang, Yanping Du, Lichao Hou, Nicholas R. J. Gascoigne, Bing Xu, Guo Fu, Qifan Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
THEMIS
CD4 + T cell progenitor
Tfh cells
chronic viral infection
GC responses
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1638178/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1638178/full

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