Inhibition of ATG5-mediated autophagy maintains PMAIP1 stability to promote cell apoptosis and suppress triple-negative breast cancer progression

Inhibition of ATG5-mediated autophagy maintains PMAIP1 stability to promote cell apoptosis and suppress triple-negative breast cancer progression

Abstract Objective Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer characterized by a high recurrence rate and a lack of effective targeted therapies. The purpose of this study was to investigate the interaction between the pro-apoptotic factor phorbol-12-myrista...

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Bibliographic Details
Main Authors: Fangjian Shang, Hongfeng Nie, Liyan Du, Jin Shang, Xiangquan Song, Ya Chen, Hui Li, Zhuo Wang, Yixin Qi, Liyan Zhao
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Discover Oncology
Subjects:
ATG5
PMAIP1
Autophagy
Apoptosis
TNBC
Online Access:https://doi.org/10.1007/s12672-025-02470-x
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https://doi.org/10.1007/s12672-025-02470-x

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