Advancements in bioengineered and autologous skin grafting techniques for skin reconstruction: a comprehensive review
The reconstruction of complex skin defects challenges clinical practice, with autologous skin grafts (ASGs) as the traditional choice due to their high graft take rate and patient compatibility. However, ASGs have limitations such as donor site morbidity, limited tissue availability, and the necessi...
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| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1461328/full |
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| author | Jillian Dean Cosima Hoch Barbara Wollenberg Justin Navidzadeh Bhagvat Maheta Anisha Mandava Samuel Knoedler Khalil Sherwani Helena Baecher Alina Schmitz Michael Alfertshofer Max Heiland Kilian Kreutzer Steffen Koerdt Leonard Knoedler |
| author_facet | Jillian Dean Cosima Hoch Barbara Wollenberg Justin Navidzadeh Bhagvat Maheta Anisha Mandava Samuel Knoedler Khalil Sherwani Helena Baecher Alina Schmitz Michael Alfertshofer Max Heiland Kilian Kreutzer Steffen Koerdt Leonard Knoedler |
| author_sort | Jillian Dean |
| collection | DOAJ |
| description | The reconstruction of complex skin defects challenges clinical practice, with autologous skin grafts (ASGs) as the traditional choice due to their high graft take rate and patient compatibility. However, ASGs have limitations such as donor site morbidity, limited tissue availability, and the necessity for multiple surgeries in severe cases. Bioengineered skin grafts (BSGs) aim to address these drawbacks through advanced tissue engineering and biomaterial science. This study conducts a systematic review to describe the benefits and shortcomings of BSGs and ASGs across wound healing efficacy, tissue integration, immunogenicity, and functional outcomes focusing on wound re-epithelialization, graft survival, and overall aesthetic outcomes. Preliminary findings suggest ASGs show superior early results, while BSGs demonstrate comparable long-term outcomes with reduced donor site morbidity. This comparative analysis enhances understanding of bioengineered alternatives in skin reconstruction, potentially redefining best practices based on efficacy, safety, and patient-centric outcomes, highlighting the need for further innovation in bioengineered solutions. |
| format | Article |
| id | doaj-art-0966cb8b85c044bc9f1c8e72786a98c0 |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-0966cb8b85c044bc9f1c8e72786a98c02025-01-07T06:51:14ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-01-011210.3389/fbioe.2024.14613281461328Advancements in bioengineered and autologous skin grafting techniques for skin reconstruction: a comprehensive reviewJillian Dean0Cosima Hoch1Barbara Wollenberg2Justin Navidzadeh3Bhagvat Maheta4Anisha Mandava5Samuel Knoedler6Khalil Sherwani7Helena Baecher8Alina Schmitz9Michael Alfertshofer10Max Heiland11Kilian Kreutzer12Steffen Koerdt13Leonard Knoedler14School of Medicine, University of Pittsburgh, Pittsburgh, PA, United StatesDepartment of Otolaryngology, Head and Neck Surgery, School of Medicine and Health, Technical University of Munich (TUM), Munich, GermanyDepartment of Otolaryngology, Head and Neck Surgery, School of Medicine and Health, Technical University of Munich (TUM), Munich, GermanySchool of Medicine, University of Pittsburgh, Pittsburgh, PA, United StatesCalifornia Northstate University College of Medicine, Elk Grove, CA, United StatesSchool of Medicine, University of Pittsburgh, Pittsburgh, PA, United StatesInstitute of Regenerative Biology and Medicine, Helmholtz Zentrum München, Munich, GermanyInstitute of Regenerative Biology and Medicine, Helmholtz Zentrum München, Munich, GermanyInstitute of Regenerative Biology and Medicine, Helmholtz Zentrum München, Munich, GermanyCharité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Department of Oral and Maxillofacial Surgery, Berlin, GermanyCharité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Department of Oral and Maxillofacial Surgery, Berlin, GermanyCharité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Department of Oral and Maxillofacial Surgery, Berlin, GermanyCharité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Department of Oral and Maxillofacial Surgery, Berlin, GermanyCharité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Department of Oral and Maxillofacial Surgery, Berlin, GermanyCharité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Department of Oral and Maxillofacial Surgery, Berlin, GermanyThe reconstruction of complex skin defects challenges clinical practice, with autologous skin grafts (ASGs) as the traditional choice due to their high graft take rate and patient compatibility. However, ASGs have limitations such as donor site morbidity, limited tissue availability, and the necessity for multiple surgeries in severe cases. Bioengineered skin grafts (BSGs) aim to address these drawbacks through advanced tissue engineering and biomaterial science. This study conducts a systematic review to describe the benefits and shortcomings of BSGs and ASGs across wound healing efficacy, tissue integration, immunogenicity, and functional outcomes focusing on wound re-epithelialization, graft survival, and overall aesthetic outcomes. Preliminary findings suggest ASGs show superior early results, while BSGs demonstrate comparable long-term outcomes with reduced donor site morbidity. This comparative analysis enhances understanding of bioengineered alternatives in skin reconstruction, potentially redefining best practices based on efficacy, safety, and patient-centric outcomes, highlighting the need for further innovation in bioengineered solutions.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1461328/fullbioengineered skin graftsautologous skin graftingskin deficitsplastic surgerydermatologic surgeryhuman skin substitute |
| spellingShingle | Jillian Dean Cosima Hoch Barbara Wollenberg Justin Navidzadeh Bhagvat Maheta Anisha Mandava Samuel Knoedler Khalil Sherwani Helena Baecher Alina Schmitz Michael Alfertshofer Max Heiland Kilian Kreutzer Steffen Koerdt Leonard Knoedler Advancements in bioengineered and autologous skin grafting techniques for skin reconstruction: a comprehensive review Frontiers in Bioengineering and Biotechnology bioengineered skin grafts autologous skin grafting skin deficits plastic surgery dermatologic surgery human skin substitute |
| title | Advancements in bioengineered and autologous skin grafting techniques for skin reconstruction: a comprehensive review |
| title_full | Advancements in bioengineered and autologous skin grafting techniques for skin reconstruction: a comprehensive review |
| title_fullStr | Advancements in bioengineered and autologous skin grafting techniques for skin reconstruction: a comprehensive review |
| title_full_unstemmed | Advancements in bioengineered and autologous skin grafting techniques for skin reconstruction: a comprehensive review |
| title_short | Advancements in bioengineered and autologous skin grafting techniques for skin reconstruction: a comprehensive review |
| title_sort | advancements in bioengineered and autologous skin grafting techniques for skin reconstruction a comprehensive review |
| topic | bioengineered skin grafts autologous skin grafting skin deficits plastic surgery dermatologic surgery human skin substitute |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1461328/full |
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