Long-term muscarinic inhibition increases intrinsic excitability through the upregulation of A-type potassium currents in cortical neurons

Neurons undergo a series of perturbations that alter their firing rate and synaptic transmission; however, they can adapt to keep a target level of electrical activity in the long term. Muscarinic receptor (mAChR) transmission modulates intrinsic excitability and allows for fast changes through phas...

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Bibliographic Details
Main Authors: Denise Riquelme, Patricia Romo-Toledo, Paula Leyton, Claudio Moreno, Elias Leiva-Salcedo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Cell and Developmental Biology
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Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1570424/full
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