Protective effects of indole-3-propionic acid against TCP-induced hearing loss in mice by mitigating oxidative stress and promoting neutrophil recruitment

Protective effects of indole-3-propionic acid against TCP-induced hearing loss in mice by mitigating oxidative stress and promoting neutrophil recruitment

Abstract Sensorineural hearing loss (SNHL) poses a significant global health challenge with substantial socioeconomic and medical implications. The pathophysiology involves excessive reactive oxygen species (ROS) in the cochlea, inflammation, cellular apoptosis, etc. Tryptophan metabolite indole-3-p...

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Main Authors: Shuangshuang Mao, Zirui Zhang, Mao Huang, Ziying Zhang, Yu Hong, Xiaohua Tan, Fei Gui, Yifei Cao, Fuzhi Lian, Rong Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-90655-3
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https://doi.org/10.1038/s41598-025-90655-3

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