A pH and GSH dual responsive nanoparticle co-deliver Adriamycin and Olaparib enhanced the therapeutic efficacy on triple negative breast cancer
A pH and GSH concentration dual responsive material was designed to address the insufficient efficacy and toxicity in triple negative breast cancer (TNBC) clinical chemotherapy. Methyl polyethylene glycol (mPEG) and oligomeric HA (o-HA) were conjugated to PLGA via hydrazone and disulfide bonds, resp...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-08-01
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| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127525006914 |
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