A pH and GSH dual responsive nanoparticle co-deliver Adriamycin and Olaparib enhanced the therapeutic efficacy on triple negative breast cancer

A pH and GSH dual responsive nanoparticle co-deliver Adriamycin and Olaparib enhanced the therapeutic efficacy on triple negative breast cancer

A pH and GSH concentration dual responsive material was designed to address the insufficient efficacy and toxicity in triple negative breast cancer (TNBC) clinical chemotherapy. Methyl polyethylene glycol (mPEG) and oligomeric HA (o-HA) were conjugated to PLGA via hydrazone and disulfide bonds, resp...

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Bibliographic Details
Main Authors: Maidong Li, Xiaofeng Wan, Benjie Shan, Yang He, Chuanrong Chen, Ming Shen
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Materials & Design
Subjects:
Microenvironment sensitive
Co-loaded NP
TNBC tumor
Orthotopic tumor and lung metastasis model
Synergetic effect
Online Access:http://www.sciencedirect.com/science/article/pii/S0264127525006914
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