Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels the molecular feature of tumor-associated neutrophils of head and neck squamous cell carcinoma

Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels the molecular feature of tumor-associated neutrophils of head and neck squamous cell carcinoma

Abstract Background Head and neck squamous cell carcinoma (HNSCC) is a lethal malignancy with a high recurrence and distant metastasis rate, posing significant challenges to patient prognosis. Recent studies suggest that tumor-associated neutrophils (TANs) can modulate immune cell infiltration and i...

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Bibliographic Details
Main Authors: Haiyang Cui, Zhikai Li, Yukun Liu, Yuchuan Yang, Linkuan Huangfu, Jinglin Kong, Xiaocong Sun, Shibo Gao, Daoke Yang, Yingjuan Zheng
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Cancer
Subjects:
Tumor-associated neutrophils
Head and neck squamous cell carcinoma
Single-cell RNA sequencing
OLR1
Online Access:https://doi.org/10.1186/s12885-025-14179-9
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https://doi.org/10.1186/s12885-025-14179-9

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