Functional and molecular single-cell analyses implicate PRDM14 in the initiation of B cell leukemia in mice

Functional and molecular single-cell analyses implicate PRDM14 in the initiation of B cell leukemia in mice

Abstract The transcription factor Prdm14 is a potent oncogene implicated in the initiation of many cancers. PRDM14 resets and maintains the pluripotent state in normal cells, but the molecular mechanisms through which PRDM14 drives oncogenesis are poorly understood. Here, we interrogated the heterog...

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Main Authors: Lauren J. Tracey, Mahmoud El-Maklizi, Dustin J. Sokolowski, Miki S. Gams, Travis Brooke-Bisschop, Julie Ruston, Christine Taylor, Alexandra Khozin, Sujeetha A. Rajakumar, Michael D. Wilson, Cynthia J. Guidos, Monica J. Justice
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-93043-z
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https://doi.org/10.1038/s41598-025-93043-z

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