Parp1 deletion rescues cerebellar hypotrophy in xrcc1 mutant zebrafish

Parp1 deletion rescues cerebellar hypotrophy in xrcc1 mutant zebrafish

Abstract Defects in DNA single-strand break repair are associated with neurodevelopmental and neurodegenerative disorders. One such disorder is that resulting from mutations in XRCC1, a scaffold protein that plays a central role in DNA single-strand base repair. XRCC1 is recruited at sites of single...

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Bibliographic Details
Main Authors: Svetlana A. Semenova, Deepthi Nammi, Grace B. Garrett, Gennady Margolin, Jennifer L. Sinclair, Reza Maroofian, Keith W. Caldecott, Harold A. Burgess
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
xrcc1
parp1
Cerebellar development
Zebrafish
Online Access:https://doi.org/10.1038/s41598-025-01870-x
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https://doi.org/10.1038/s41598-025-01870-x

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