Considerations for developing CYP induction assays in hepatocytes: Insights from a multilaboratory study

Considerations for developing CYP induction assays in hepatocytes: Insights from a multilaboratory study

Cytochrome P450 (CYP) induction studies using primary human hepatocytes (PHH) were conducted across seven laboratories. Standard operating procedures (SOPs) were developed and distributed, ensuring all laboratories used PHH from the same donor and CYP inducers prepared at a single location. In each...

Full description

Saved in:
Bibliographic Details
Main Authors: Hiroko Toyoda, Ayaka Nozue, Yuki Nishida, Yasuko Yakabe, Yasuhiko Aiki, Yukiko Ueyama-Toba, Kazuo Takayama, Hiroyuki Mizuguchi, Chihiro Mori, Yu-suke Torisawa, Yoko Sakai, Takahiro Iwao, Tamihide Matsunaga, Shinichiro Horiuchi, Daiju Yamazaki, Seiichi Ishida, Nobuhiko Kojima, Kosuke Inamura, Yasuyuki Sakai, Masaki Nishikawa, Ikue Mihara, Takafumi Akabane, Yuzuru Ito
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:European Journal of Cell Biology
Subjects:
Analytical method
Primary human hepatocyte
CYP induction
Multilaboratory study
Standard operating procedure
Online Access:http://www.sciencedirect.com/science/article/pii/S0171933525000226
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S0171933525000226

Similar Items