Saliva-based lacosamide monitoring paves the way toward personalized epilepsy pharmacotherapy

Saliva-based lacosamide monitoring paves the way toward personalized epilepsy pharmacotherapy

Abstract Saliva, known for better patient compliance and simpler collection, is ideal for monitoring antiseizure medication (ASM) levels. This study aimed to validate saliva for measuring lacosamide, develop a pharmacokinetic (PK) model, and determine the optimal saliva concentration for seizure con...

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Main Authors: Yoonhyuk Jang, Seon-Jae Ahn, Soyoung Lee, Yongmoo Kim, Han Sang Lee, Yoon-Kyung Lee, Yong Woo Shin, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Ki-Young Jung, Joo-Youn Cho, SeungHwan Lee, Kyung-Sang Yu, Kon Chu, In-Jin Jang, Sang Kun Lee
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Saliva-based TDM
Lacosamide
Personalized medicine
Lacosamide pharmacokinetics
Online Access:https://doi.org/10.1038/s41598-025-04044-x
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https://doi.org/10.1038/s41598-025-04044-x

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