Exploring 4,7-Disubstituted Pyrimido[4,5-<i>d</i>]pyrimidines as Antiviral and Anticancer Agents

Exploring 4,7-Disubstituted Pyrimido[4,5-<i>d</i>]pyrimidines as Antiviral and Anticancer Agents

Thirteen new 4,7-disubstituted pyrimido[4,5-<i>d</i>]pyrimidines were synthesized via a straightforward methodology starting from thiourea. The anti-proliferative activity of these compounds was evaluated across a diverse panel of eight cancer cell lines, with derivatives <b>7d<...

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Bibliographic Details
Main Authors: Eleftheria A. Georgiou, Konstantinos Paraskevas, Christina Koutra, Leentje Persoons, Dominique Schols, Steven De Jonghe, Ioannis K. Kostakis
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Molecules
Subjects:
pyrimido[4,5-<i>d</i>]pyrimidines
synthesis
antiviral activity
anti-proliferative activity
HCoV-229E
Online Access:https://www.mdpi.com/1420-3049/29/23/5549
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