An Evaluation of the Safety, Immunogenicity, and Protective Efficacy of a Combined Diphtheria–Tetanus–Acellular Pertussis, <i>Haemophilus influenzae</i> Type b, and ACYW135 Meningococcal Conjugate Vaccine in Murine and Rat Models

An Evaluation of the Safety, Immunogenicity, and Protective Efficacy of a Combined Diphtheria–Tetanus–Acellular Pertussis, <i>Haemophilus influenzae</i> Type b, and ACYW135 Meningococcal Conjugate Vaccine in Murine and Rat Models

<b>Background</b>: The combined diphtheria–tetanus–acellular pertussis (three-component), <i>Haemophilus influenzae</i> type b (Hib, conjugate), and ACYW135 meningococcal (conjugate) vaccine (DTaP-Hib-MCV4) offers a promising alternative to single-component vaccines, potentia...

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Bibliographic Details
Main Authors: Xiuwen Sui, Zhujun Shao, Yuanyuan Ji, Hairui Wang, Qingfu Xu, Bochao Wei, Zhuojun Duan, Chang Wang, Ying Yang, Jiayu Zhao, Tao Zhu
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Vaccines
Subjects:
Combined Diphtheria-Tetanus-Acellular Pertussis
<i>Haemophilus influenzae</i> Type b
ACYW135 Meningococcal Conjugate Vaccine
safety
immunogenicity
protective efficacy
Online Access:https://www.mdpi.com/2076-393X/13/7/724
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