Subacute parkinsonism induced by immune checkpoint inhibitors
Immune checkpoint inhibitors can trigger immune-related side effects, and while neurological involvement is rare, it can be serious. A woman with treatment-refractory intestinal T-cell lymphoma was initiated pembrolizumab and developed a daily fever and parkinsonian syndrome 2 weeks later. The inves...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
|
| Series: | Annals of Movement Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.4103/aomd.aomd_40_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841525512952872960 |
|---|---|
| author | Lénia Silva Inês Laranjinha Cláudia Casais Raquel Samões |
| author_facet | Lénia Silva Inês Laranjinha Cláudia Casais Raquel Samões |
| author_sort | Lénia Silva |
| collection | DOAJ |
| description | Immune checkpoint inhibitors can trigger immune-related side effects, and while neurological involvement is rare, it can be serious. A woman with treatment-refractory intestinal T-cell lymphoma was initiated pembrolizumab and developed a daily fever and parkinsonian syndrome 2 weeks later. The investigation revealed only mild slowing of the background activity on electroencephalogram and slightly elevated cell count and protein levels in her cerebrospinal fluid. Immunotherapy was discontinued, and the patient recovered after 5 days of methylprednisolone. Minor neurological symptoms recurred after the rechallenge with pembrolizumab. Subacute parkinsonian syndromes should be considered a potential neurological event related to immune checkpoint inhibitors. |
| format | Article |
| id | doaj-art-08c840eed621490384c42722cf36a36c |
| institution | Kabale University |
| issn | 2590-3446 2590-3454 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Movement Disorders |
| spelling | doaj-art-08c840eed621490384c42722cf36a36c2025-01-17T10:41:07ZengWolters Kluwer Medknow PublicationsAnnals of Movement Disorders2590-34462590-34542024-12-017322422610.4103/aomd.aomd_40_24Subacute parkinsonism induced by immune checkpoint inhibitorsLénia SilvaInês LaranjinhaCláudia CasaisRaquel SamõesImmune checkpoint inhibitors can trigger immune-related side effects, and while neurological involvement is rare, it can be serious. A woman with treatment-refractory intestinal T-cell lymphoma was initiated pembrolizumab and developed a daily fever and parkinsonian syndrome 2 weeks later. The investigation revealed only mild slowing of the background activity on electroencephalogram and slightly elevated cell count and protein levels in her cerebrospinal fluid. Immunotherapy was discontinued, and the patient recovered after 5 days of methylprednisolone. Minor neurological symptoms recurred after the rechallenge with pembrolizumab. Subacute parkinsonian syndromes should be considered a potential neurological event related to immune checkpoint inhibitors.https://doi.org/10.4103/aomd.aomd_40_24immune checkpoint inhibitorparkinsonismpembrolizumab |
| spellingShingle | Lénia Silva Inês Laranjinha Cláudia Casais Raquel Samões Subacute parkinsonism induced by immune checkpoint inhibitors Annals of Movement Disorders immune checkpoint inhibitor parkinsonism pembrolizumab |
| title | Subacute parkinsonism induced by immune checkpoint inhibitors |
| title_full | Subacute parkinsonism induced by immune checkpoint inhibitors |
| title_fullStr | Subacute parkinsonism induced by immune checkpoint inhibitors |
| title_full_unstemmed | Subacute parkinsonism induced by immune checkpoint inhibitors |
| title_short | Subacute parkinsonism induced by immune checkpoint inhibitors |
| title_sort | subacute parkinsonism induced by immune checkpoint inhibitors |
| topic | immune checkpoint inhibitor parkinsonism pembrolizumab |
| url | https://doi.org/10.4103/aomd.aomd_40_24 |
| work_keys_str_mv | AT leniasilva subacuteparkinsonisminducedbyimmunecheckpointinhibitors AT ineslaranjinha subacuteparkinsonisminducedbyimmunecheckpointinhibitors AT claudiacasais subacuteparkinsonisminducedbyimmunecheckpointinhibitors AT raquelsamoes subacuteparkinsonisminducedbyimmunecheckpointinhibitors |